Osborne P G, Denton D A, Weisinger R S
Physiol Behav. 1986;37(1):1-4. doi: 10.1016/0031-9384(86)90374-4.
Increases in cerebrospinal fluid pressure (CSFP) were measured in the lateral ventricle in barbiturate anaesthetized male Sprague Dawley rats during intracerebroventricular (IVT) infusions into the contralateral ventricle. IVT infusions of isotonic artificial CSF (art-CSF) solutions at 10 and 38 microliters/hr increased mean CSFP from control preinfusion level of 3.6 cm H2O to 4.6 cm H20 (n.s.) and 5.2 cm H2O (p less than 0.01) respectively with CSFP appearing to attain equilibrium after 30-60 min of infusion. IVT infusion of hyperosmolar art CSF solutions (saccharide and salt solutions of approximate 1000 mOsm/kg) at 38 microliters/hr resulted in a larger increase of CSFP which equilibrated at 8.5 cm H2O (p less than 0.001) after 90 min of infusion. It is suggested that on the basis of CSFP measurements in these and other experiments cited that IVT infusions be run at infusion rates of less than 40 microliters/hr to ensure minimal physiological change.
在对巴比妥麻醉的雄性斯普拉格-道利大鼠进行对侧脑室内（IVT）输注期间，测量其侧脑室内的脑脊液压力（CSFP）升高情况。以每小时10微升和38微升的速度IVT输注等渗人工脑脊液（art-CSF）溶液，分别使平均CSFP从输注前的对照水平3.6厘米水柱升高到4.6厘米水柱（无统计学意义）和5.2厘米水柱（p<0.01），输注30 - 60分钟后CSFP似乎达到平衡。以每小时38微升的速度IVT输注高渗art-CSF溶液（约1000毫摩尔/千克的糖类和盐溶液），导致CSFP有更大幅度的升高，输注90分钟后在8.5厘米水柱达到平衡（p<0.001）。根据这些实验以及引用的其他实验中的CSFP测量结果，建议IVT输注的速率应低于每小时40微升，以确保生理变化最小。
