Osborne P G, Denton D A, Weisinger R S
Behav Neurosci. 1987 Jun;101(3):371-7. doi: 10.1037//0735-7044.101.3.371.
Infusing conscious unrestrained rats with either 0.5 M NaCl-CSF or 0.7 M sucrose-CSF into the lateral cerebral ventricle (IVT) at 38 microliters/hr for 4 hr induced drinking. Although the infusates were nearly equiosmotic, water drinking during the 0.5 M NaCl-CSF was greater than during 0.7 M sucrose-CSF. However, IVT infusions of 0.7 M mannitol-CSF at rates of 9.4 microliters/hr or 38 microliters/hr for 4 hr or 10 microliters/hr for 4 days failed to induce water drinking. Also, IVT infusion of 0.27 M mannitol-CSF at 38 microliters/hr for 4 hr failed to significantly alter water drinking. CSF [Na] was reduced by IVT infusion of either 0.7 M sucrose-CSF or 0.7 M mannitol-CSF. In contrast, CSF [Na] was increased by 4-hr IVT infusion of 0.5 M NaCl in rats denied access to water during the infusion. Intake of 0.5 M NaCl was not altered significantly from control intakes by any of the above IVT infusions. It is concluded that water drinking in the rat may be initiated by stimulation of either a sodium sensitive sensor alone or with an osmoreceptor system and that species specific differences in the induction of both water drinking and hypertonic saline drinking are apparent.
以38微升/小时的速度向清醒且不受限制的大鼠侧脑室（IVT）内注入0.5M NaCl -脑脊液或0.7M蔗糖 -脑脊液，持续4小时可诱导饮水。尽管注入液几乎等渗，但0.5M NaCl -脑脊液注入期间的饮水比0.7M蔗糖 -脑脊液注入期间更多。然而，以9.4微升/小时或38微升/小时的速度向IVT注入0.7M甘露醇 -脑脊液4小时，或以10微升/小时的速度注入4天，均未能诱导饮水。此外，以38微升/小时的速度向IVT注入0.27M甘露醇 -脑脊液4小时，也未能显著改变饮水情况。通过向IVT注入0.7M蔗糖 -脑脊液或0.7M甘露醇 -脑脊液可降低脑脊液[Na]。相反，在注入期间不给大鼠饮水的情况下，向IVT注入0.5M NaCl 4小时可使脑脊液[Na]升高。上述任何一种IVT注入均未使0.5M NaCl的摄入量与对照摄入量有显著差异。得出的结论是，大鼠的饮水可能由单独刺激钠敏感传感器或与渗透压感受器系统共同刺激引发，并且在饮水和高渗盐水饮用诱导方面的物种特异性差异很明显。
