Evaluation of the hepatoprotective effect of combination between fermented camel milk and leaves extract against CCl induced liver toxicity in mice.

The present study was conducted to evaluate the in vitro antioxidant activity of fermented camel milk with subsp. (FCM-LLC) alone, extract (R) alone and their combination and to investigate their hepatopreventive effects against CCl liver damage in mice. The antioxidant activity in vitro of FMC-LLC supplemented with R exhibited the highest free radical scavenging and ferric reducing power activities. The results showed that the pretreatment with a combination of FMC-LLC and R significantly alleviated the increased levels of hepatic markers and the elevated lipid levels induced by CCl in mice. Meanwhile, the enzymatic antioxidants activities (superoxide dismutase, glutathione peroxidase, and catalase) and GSH level in liver significantly were increased while the malondialdehyde level was significantly improved by pretreatment with FMLLC plus R. These data suggest that FCM-LLC in combination with extract possesses better antioxidant and hepatoprotective activity than FMC-LLC alone.