Setiawan I Gusti Ngurah Yudhi, Suyasa I Ketut, Astawa Putu, Dusak I Wayan Suryanto, Kawiyana I Ketut Siki, Aryana I Gusti Ngurah Wien
Department of Orthopaedic and Traumatology, Udayana Faculty of Medicine, Indonesia.
J Orthop. 2019 Mar 2;16(3):230-233. doi: 10.1016/j.jor.2019.02.028. eCollection 2019 May-Jun.
Osteoarthritis (OA) arises from imbalance of cartilage metabolism between the synthesis and degradation of type II collagen by the chondrocyte. Collagen type II degradation is characterized by increase in the biomarker of C-telopeptide fragment of type II collagen (CTX-II), while the anabolic process of cartilage is characterized by an increase in the biosynthesis of procollagen amino terminal N-propeptide type IIA (PIIANP). Platelet derived growth factor (PDGF) with Hyaluronic Acid (HA) as a potent growth factor can be used to stimulate the higher formation of chondrocyte and PIIANP levels and lower CTX-II levels in mouse knee osteoarthritis model.
骨关节炎（OA）源于软骨细胞对II型胶原蛋白合成与降解之间的软骨代谢失衡。II型胶原蛋白降解的特征是II型胶原蛋白C端肽片段（CTX-II）生物标志物增加，而软骨的合成代谢过程的特征是IIA型前胶原氨基末端N-前肽（PIIANP）生物合成增加。以透明质酸（HA）作为一种强效生长因子的血小板衍生生长因子（PDGF）可用于刺激小鼠膝骨关节炎模型中软骨细胞的更高形成以及PIIANP水平升高和CTX-II水平降低。
