Petrov V N, Budagov R S, Khlopovskaia E I, Konov A V, Podgorodnichenko V K
Radiobiologiia. 1986 May-Jun;26(3):351-5.
The electrophoretic and immunoelectrophoretic methods were used to study fibronectin of blood plasma of intact Wistar rats and of those exposed to 1-10 Gy radiation. The increase in the fibronectin concentration 3 days after irradiation was a function of radiation dose. Possible mechanisms of the hyperfibronectinemia development involving mechanisms of endogenous proteolytic fragmentation of glycoprotein, the increase in the protein synthesis and complexation and inhibition of the rate of fibronectin degradation and elimination are discussed.
采用电泳和免疫电泳方法研究了未受照射的Wistar大鼠以及受1-10 Gy辐射的大鼠血浆中的纤连蛋白。照射后3天纤连蛋白浓度的增加是辐射剂量的函数。讨论了高纤连蛋白血症发生的可能机制，包括糖蛋白内源性蛋白水解片段化机制、蛋白质合成增加、复合作用以及纤连蛋白降解和清除速率的抑制。
