Ermolin G A, Litvinov R I, Kharin G M, Efremov E E, Kotelianskiĭ V E
Ter Arkh. 1984;56(6):33-5.
The blood fibronectin concentration in rats was measured by the ELISA during burn shock. Fifteen minutes after burn the fibronectin level was found to drop by 30% of the initial level on the average. Deep hypofibronectinemis lasted up to 24 h after burn. At the same time the clinical and pathomorphological picture of the shock was fairly pronounced. The survived animals demonstrated a progressive normalization of the fibronectin level. The fibronectin level completely returned to normal by the outcome of the second day after burn and then progressed to reactive hyperfibronectinemia by 70-72 h. The data obtained point to the involvement of fibronectin into the pathogenesis of burn shock, which is likely to be connected with the mechanism of reticuloendothelial system dysfunction.
在烧伤休克期间，通过酶联免疫吸附测定法（ELISA）测量大鼠血液中的纤连蛋白浓度。烧伤后15分钟，发现纤连蛋白水平平均下降至初始水平的30%。深度低纤连蛋白血症在烧伤后持续长达24小时。与此同时，休克的临床和病理形态学表现相当明显。存活的动物显示纤连蛋白水平逐渐恢复正常。烧伤后第二天结束时，纤连蛋白水平完全恢复正常，然后在70 - 72小时进展为反应性高纤连蛋白血症。所获得的数据表明纤连蛋白参与了烧伤休克的发病机制，这可能与网状内皮系统功能障碍的机制有关。
