一名韩国中风患者出现无梭状回受累的表意性失读症：一项系列功能磁共振成像研究
Ideographic Alexia without Involvement of the Fusiform Gyrus in a Korean Stroke Patient: A Serial Functional Magnetic Resonance Imaging Study.
作者信息
Yang Jiwon, Kim Nambeom, Lee Hyon, Park Kee Hyung
机构信息
Department of Neurology, Gil Medical Center, Gachon University, Incheon, Korea.
Neuroscience Research Institute, Gachon University, Incheon, Korea.
出版信息
Dement Neurocogn Disord. 2016 Sep;15(3):82-87. doi: 10.12779/dnd.2016.15.3.82. Epub 2016 Sep 30.
BACKGROUND
Korean orthography is composed of Hanja (ideograms) and Hangul (phonograms). Based on previous studies, the fusiform gyrus has been associated with ideogram reading. We examine serial functional magnetic resonance imaging (fMRI) images in a patient exhibiting dissociation of Hanja and Hangul reading to identify brain areas associated with Hanja reading.
CASE REPORT
fMRI were taken of a 63-year-old man showing profound Hanja alexia with normal Hangul reading after an acute stroke involving the left frontal and parietal lobes, who later spontaneously recovered his Hanja reading ability. Scans were taken while performing Hanja and Hangul reading tasks on three occasions. As a result, in spite of having profound Hanja alexia, partial activation of the fusiform gyrus was observed on the first fMRI. Serial fMRI scans showed activation of the bilateral middle frontal gyri that increased in parallel with the patient's recovery of Hanja reading.
CONCLUSIONS
The frontal lobe, not only fusiform gyrus, may play role in reading Hanja, although more evidence is needed.
背景
韩文拼写由汉字（表意文字）和韩文（音素文字）组成。基于先前的研究，梭状回与表意文字阅读有关。我们对一名表现出汉字和韩文阅读分离的患者进行了系列功能磁共振成像（fMRI）检查，以确定与汉字阅读相关的脑区。
病例报告
对一名63岁男性进行了fMRI检查，该患者在涉及左额叶和顶叶的急性中风后出现严重的汉字失读症，但韩文阅读正常，随后他自发恢复了汉字阅读能力。在三个不同时间点进行汉字和韩文阅读任务时进行了扫描。结果，尽管该患者有严重的汉字失读症，但在第一次fMRI检查时仍观察到梭状回有部分激活。系列fMRI扫描显示双侧额中回激活，且随着患者汉字阅读能力的恢复而增强。
结论
额叶，而非仅梭状回，可能在汉字阅读中起作用，尽管还需要更多证据。
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