Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
AJNR Am J Neuroradiol. 2010 Jun;31(6):990-6. doi: 10.3174/ajnr.A1896. Epub 2009 Dec 10.
BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article.
BOLD fMRI 通过提供一种非侵入性的体内方法来评估语言任务期间大脑皮质激活的纵向变化，为研究损伤后大脑语言可塑性提供了新的见解。具体来说，BOLD fMRI 提供了机会不仅可以研究不同类型的脑病理（如脑肿瘤、中风和癫痫）导致的语言中枢大脑皮质的变化，还可以研究由于实际切除病变但仍具有部分功能的组织而导致的语言中枢大脑皮质的变化。除了回顾与中风和癫痫相关的语言可塑性以及肿瘤背景下更有趣的手术后可塑性现象的文献外，本文还简要描述了这两种语言可塑性后表现的 2 个不寻常病例。
