Jo Kyunghwa, Jhoo Jin Hyeong, Mun Young-Ju, Kim Yeon Mi, Kim Sung Keun, Kim Seongheon, Lee Seung-Hwan, Jang Jae-Won
Department of Psychiatry, Kangwon National University Hospital, Chuncheon, Korea.
Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea.
Dement Neurocogn Disord. 2018 Mar;17(1):23-31. doi: 10.12779/dnd.2018.17.1.23. Epub 2018 Mar 14.
The effect of cognitive intervention in patients with dementia is inconsistent. This study sought to find out the effect of cognitive intervention by measuring interval change between before and after intervention.
We evaluated cognitive changes according to clinical diagnostic group across Gangwon province for 940 patients with dementia diagnosed at hospital clinics and 2,975 subjects without dementia. All subjects were treated with cognitive intervention. They underwent a cognitive and mood assessment before and after intervention. We used interval change of Mini-Mental State Examination (MMSE) scores as a primary measure of interventional outcome.
Changes in mean MMSE score were significantly different between the non-dementia group and the dementia group (=0.016), with changes of 0.7±2.4 and 1.0±3.7 points (±standard deviation), respectively. Cognitive improvement regarding completion of session was significantly higher in the dementia group (=0.001), with changes of 0.41±4.51 for uncompleted group and 1.30±3.22 points for completed ones. Lower initial MMSE scores, lower age, and type of intervention were found to be independent predictive factors of subsequent cognitive changes as indicated by mean MMSE scores.
These findings suggest that cognitive intervention might be useful for patients with dementia. Their response to treatment might be related to the type of intervention.
认知干预对痴呆患者的效果并不一致。本研究旨在通过测量干预前后的间隔变化来探究认知干预的效果。
我们对江原道地区医院门诊诊断的940例痴呆患者和2975例非痴呆受试者，根据临床诊断组评估认知变化。所有受试者均接受认知干预。他们在干预前后进行了认知和情绪评估。我们将简易精神状态检查表（MMSE）分数的间隔变化作为干预结果的主要衡量指标。
非痴呆组和痴呆组的平均MMSE分数变化存在显著差异（=0.016），分别变化了0.7±2.4分和1.0±3.7分（±标准差）。痴呆组在课程完成方面的认知改善显著更高（=0.001），未完成组变化了0.41±4.51分，完成组变化了1.30±3.22分。较低的初始MMSE分数、较低的年龄和干预类型被发现是后续认知变化的独立预测因素，如平均MMSE分数所示。
这些发现表明认知干预可能对痴呆患者有用。他们对治疗的反应可能与干预类型有关。
