5-氟尿嘧啶与丝裂霉素C治疗晚期乳腺癌
5-Fluorouracil and mitomycin C in advanced breast cancer.
作者信息
Aspegren K, Landberg T
出版信息
Radiother Oncol. 1986 Jun;6(2):121-6. doi: 10.1016/s0167-8140(86)80018-4.
Fifty-seven patients with advanced breast cancer were treated with a combination of 5-fluorouracil and mitomycin C (FuMi). Fifty-three were previously treated with hormones and/or cytotoxic drugs. Complete and partial remissions (CR, PR) were seen in 16%, stationary disease in 46%, and progressive disease in 38%. The mean time to remission was 4.5 (CR) to 4.0 (PR) months. The toxicity was mild and consisted mainly of thrombocytopenia. The FuMi-regimen may be a useful alternative in advanced breast cancer, at least in progression after previous systemic therapy, and if a moderate toxicity is considered important.
57例晚期乳腺癌患者接受了5-氟尿嘧啶和丝裂霉素C联合治疗（FuMi）。其中53例患者先前接受过激素和/或细胞毒性药物治疗。完全缓解和部分缓解（CR，PR）率为16%，病情稳定率为46%，病情进展率为38%。缓解的平均时间为4.5个月（CR）至4.0个月（PR）。毒性较轻，主要为血小板减少。FuMi方案可能是晚期乳腺癌的一种有效替代方案，至少适用于先前全身治疗后病情进展且认为中度毒性较为重要的情况。
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