Sebes J I, Niell H B, Palmieri G M, Reidy T J
Skeletal Radiol. 1986;15(5):354-9. doi: 10.1007/BF00348861.
Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations. Twenty receiving chemotherapy were also followed with skeletal surveys in order to evaluate bone response to treatment. A close association was found between skeletal findings and changes in immunoglobulin levels with positive correlation in 71% of the patients. A similar association was found between skeletal disease and Spot-HYPRO level changes in 65%. Five of 12 patients (42%) with partial or complete clinical response to chemotherapy, demonstrated improvement in the appearance of skeletal lesions. Positive correlation between the roentgenographic changes and clinical markers of myeloma as well as therapeutic response, indicates that skeletal surveys are useful and effective in monitoring patients with multiple myeloma.
对33例多发性骨髓瘤患者进行了系列骨骼检查、血清免疫球蛋白水平测定以及吸收后尿羟脯氨酸（Spot-HYPRO）测定。20例接受化疗的患者也进行了骨骼检查，以评估骨骼对治疗的反应。在骨骼检查结果与免疫球蛋白水平变化之间发现密切关联，71%的患者呈正相关。在骨骼疾病与Spot-HYPRO水平变化之间也发现了类似的关联，占65%。12例对化疗有部分或完全临床反应的患者中有5例（42%）骨骼病变外观有所改善。X线变化与骨髓瘤临床指标以及治疗反应之间的正相关表明，骨骼检查在监测多发性骨髓瘤患者方面是有用且有效的。
