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诊断 GOSE:使用项目反应理论的结构和心理计量学特性,TRACK-TBI 初步研究。

Diagnosing the GOSE: Structural and Psychometric Properties Using Item Response Theory, a TRACK-TBI Pilot Study.

机构信息

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Department of Psychology, Marquette University, Milwaukee, Wisconsin.

出版信息

J Neurotrauma. 2019 Sep 1;36(17):2493-2505. doi: 10.1089/neu.2018.5998. Epub 2019 May 23.

Abstract

The Glasgow Outcome Scale-Extended (GOSE) was designed to assess global outcome after traumatic brain injury (TBI). Since its introduction, several empirically founded criticisms of the GOSE have been raised, including poor reliability; an insensitivity to small, but potentially meaningful, changes; a tendency to produce ceiling effects; inconsistent associations with neurocognitive, psychological, and quality-of-life measures; and an inability to assess the multi-dimensional nature of TBI outcome. The current project took a diagnostic approach to identifying the underlying causes of reported limitations by exploring the internal construct validity of the GOSE at 3 and 6 months post-injury using item response theory (IRT) techniques. Data were from the TRACK-TBI Pilot Study, a large ( = 586), prospective, multi-site project that included TBI cases of all injury severity levels. To assess the level of latent functional "impairment" captured by GOSE items independent of the assigned outcome category or GOSE total score, items were modified so that higher scores reflected greater impairment. Results showed that although the GOSE's items capture varying levels of impairment across a broad disability spectrum at 3 and 6 months, there was also evidence at each time point of item redundancy (multiple items capturing similar levels of impairment), item deficiency (lack of items capturing lower levels of impairment), and item inefficiency (items only capturing minimal impairment information). The findings illustrate the value of IRT to illuminate strengths and weaknesses of clinical outcome assessment measures and provide a framework for future measure refinement.

摘要

格拉斯哥结局量表-扩展版(GOSE)旨在评估创伤性脑损伤(TBI)后的总体结局。自推出以来,针对 GOSE 提出了一些基于经验的批评,包括可靠性差;对小但可能有意义的变化不敏感;产生上限效应的趋势;与神经认知、心理和生活质量测量的关联不一致;以及无法评估 TBI 结局的多维性质。本研究采用诊断方法,通过使用项目反应理论(IRT)技术在损伤后 3 个月和 6 个月探索 GOSE 的内部结构效度,来确定报告限制的潜在原因。数据来自 TRACK-TBI 初步研究,这是一个大型( = 586)、前瞻性、多地点项目,包括所有损伤严重程度的 TBI 病例。为了评估 GOSE 项目独立于分配的结局类别或 GOSE 总分所捕获的潜在功能“损伤”水平,对项目进行了修改,以使更高的分数反映更大的损伤。结果表明,尽管 GOSE 的项目在 3 个月和 6 个月时在广泛的残疾范围内捕捉到了不同程度的损伤,但在每个时间点也有证据表明项目存在冗余(多个项目捕捉相似水平的损伤)、项目不足(缺乏捕捉较低水平损伤的项目)和项目效率低下(项目仅捕捉最小的损伤信息)。研究结果说明了 IRT 在阐明临床结局评估测量的优缺点方面的价值,并为未来的测量改进提供了框架。

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