Department of Intensive Care, 4131, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Centre for Research in Intensive Care (CRIC), Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2019 Aug;63(7):966-972. doi: 10.1111/aas.13361. Epub 2019 Mar 25.
Stress ulcer prophylaxis is the considered standard of care in many critically ill patients in the intensive care unit (ICU). Whether there is overall benefit or harm of stress ulcer prophylaxis in critically ill children is unknown. Accordingly, we aim to assess patient-important benefits and harms of stress ulcer prophylaxis versus placebo or no treatment in critically ill children in the ICU.
METHODS/DESIGN: We will conduct a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis and assess the use of proton pump inhibitors (PPIs) or histamine-2-receptor antagonists (H2RAs) versus placebo or no prophylaxis. We will systematically search the Cochrane Library, MEDLINE, EMBASE, Science Citation Index, BIOSIS, and Epistemonikos for relevant literature. We will follow the recommendations by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The risk of systematic errors (bias) and random errors will be assessed, and the overall quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
There is a need for an updated systematic review to summarize the benefits and harms of stress ulcer prophylaxis in critically ill children to inform practice and future research.
在重症监护病房（ICU）中，应激性溃疡预防被认为是许多危重症患者的标准治疗方法。应激性溃疡预防在危重症儿童中的总体获益或危害尚不清楚。因此，我们旨在评估应激性溃疡预防与安慰剂或不治疗相比，对 ICU 中危重症儿童的患者重要获益和危害。
方法/设计：我们将对随机临床试验进行系统评价，进行荟萃分析和试验序贯分析，并评估质子泵抑制剂（PPIs）或组胺 2 受体拮抗剂（H2RAs）与安慰剂或不预防的使用。我们将系统地搜索 Cochrane 图书馆、MEDLINE、EMBASE、科学引文索引、BIOSIS 和 Epistemonikos 中的相关文献。我们将遵循 Cochrane 协作和系统评价和荟萃分析的首选报告项目（PRISMA）声明的建议。将评估系统误差（偏倚）和随机误差的风险，并根据推荐评估、制定和评价（GRADE）方法评估证据的总体质量。
需要更新系统评价，以总结应激性溃疡预防在危重症儿童中的获益和危害，为实践和未来研究提供信息。
