Vaalasti A, Alho A M, Tainio H, Hervonen A
Acta Histochem. 1986;79(1):49-54. doi: 10.1016/S0065-1281(86)80099-X.
The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on the ventral prostate of the rat was studied. A dose of 50 mg/kg i.v., which was repeated after 1 week, was effective enough to produce total disappearance of sympathetic nerves. Reappearance of nerve fibres was evident 2 weeks after treatment. Dilation of prostatic alveoli was noted 1 week after denervation. It is concluded that the absence of normal sympathetic innervation prevents the emptying of the rat prostate.
研究了用6-羟基多巴胺（6-OHDA）进行化学性交感神经切除术对大鼠腹侧前列腺的影响。静脉注射剂量为50mg/kg，1周后重复给药，足以使交感神经完全消失。治疗后2周神经纤维明显重新出现。去神经支配1周后可见前列腺腺泡扩张。结论是正常交感神经支配的缺失会阻碍大鼠前列腺的排空。
