Yao Xiang, Wei Ting, Zhang Haoran, Li Jialin, Tang Aiwen, Ren Ke
Department of Radiology, The Xiang'An Hospital of Xia Men Uneversity, Xia Men.
The Hospital of North Sichuan Medical College, Nan Chong, China.
J Craniofac Surg. 2019 Jun;30(4):1231-1233. doi: 10.1097/SCS.0000000000005468.
In the present study, the authors assessed the differences in natural growth rates between skull base and non-skull base meningiomas by meta-analysis. Studies investigating meningioma growth rate were compiled from PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature database, and the China National Knowledge Infrastructure databases. A systematic review and meta-analysis of the collected literature were conducted using Stata 12.0 software. A total of 7 observational cohort studies, including 361 patients with untreated meningiomas, were included in the study. Meta-analysis showed that the weighted mean difference for absolute growth rate (years), relative growth rate (years), and doubling time (month) were 0.42 (95% confidence interval [CI]: 0.20-0.64, P <.0001), 1.08 (95%CI: 0.85-1.32, P <.0001), and -0.56 [95%CI: (-0.78)-(-0.33), P <.0001)] respectively. These findings indicate that the natural growth rate of skull base meningioma is less than that of non-skull base meningioma.
在本研究中，作者通过荟萃分析评估了颅底脑膜瘤和非颅底脑膜瘤自然生长率的差异。从PubMed、Embase、Cochrane对照试验中央注册库、中国生物医学文献数据库和中国知网数据库中收集了有关脑膜瘤生长率的研究。使用Stata 12.0软件对收集到的文献进行系统评价和荟萃分析。该研究共纳入7项观察性队列研究，包括361例未经治疗的脑膜瘤患者。荟萃分析显示，绝对生长率（年）、相对生长率（年）和倍增时间（月）的加权平均差分别为0.42（95%置信区间[CI]：0.20 - 0.64，P <.0001）、1.08（95%CI：0.85 - 1.32，P <.0001）和 -0.56 [95%CI：(-0.78)-(-0.33)，P <.0001]。这些结果表明，颅底脑膜瘤的自然生长率低于非颅底脑膜瘤。
