Department of Biosciences, Federal University of São Paulo, São Paulo, Brazil.
Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.
J Strength Cond Res. 2019 Apr;33(4):1119-1129. doi: 10.1519/JSC.0000000000002355.
Montrezol, FT, Marinho, R, Mota, GdFAd, D'almeida, V, de Oliveira, EM, Gomes, RJ, and Medeiros, A. ACE gene plays a key role in reducing blood pressure in the hyperintensive elderly after resistance training. J Strength Cond Res 33(4): 1119-1129, 2019-Hypertension is a difficult disease to control and exercise training plays a key role in hypertension control. Some individuals are not responsive to exercise training; so, we highlight the polymorphism of I allele of angiotensin-converting enzyme (ACE) as a factor responsible for this lack of responsiveness. The aim of this study was to evaluate the influence of ACE insertion/deletion genotypes on effects of resistance training on blood pressure (BP) and chronic inflammation. Eighty-six hypertensive volunteers, aged between 60 and 80, were evaluated. They performed 16 weeks of resistance training at 50% of 1 maximal repetition. The greatest benefits were seen on homozygous of the Insertion allele, whom presented reduction of systolic blood pressure (SBP: 129.31 ± 13.34 vs. 122.56 ± 9.68 mm Hg, p < 0.001) and diastolic blood pressure (DBP: 79.18 ± 8.05 vs. 70.12 ± 7.71 mm Hg, p < 0.01) during daytime period, and in 24-hour period (SBP: 127.12 ± 13.65 vs. 121.06± 9.68 mm Hg, p < 0.001 and DBP: 71.87 ± 8.39 vs. 68.75 ± 8.72 mm Hg, p < 0.05) and also increased circulating adiponectin levels (4.04 ± 1.79 vs. 6.00 ± 2.81 ng·ml, p < 0.01). Other genotypes showed no changes in BP and biochemical parameters. Our results suggest a cardio protective factor of I allele because only those homozygous showed reductions in BP and increases in adiponectin.
蒙泰罗，FT，马里尼奥，R，莫塔，GdFAd，德阿尔梅达，V，德奥利韦拉，EM，戈麦斯，RJ，和梅代罗斯，A。ACE 基因在高血压老年患者进行抗阻训练后降低血压方面起着关键作用。J Strength Cond Res 33(4):1119-1129,2019-高血压是一种难以控制的疾病，运动训练在高血压的控制中起着关键作用。有些人对抗阻训练没有反应；因此，我们强调血管紧张素转换酶（ACE）I 等位基因的多态性是导致这种无反应的一个因素。本研究旨在评估 ACE 插入/缺失基因型对阻力训练对血压（BP）和慢性炎症的影响。评估了 86 名年龄在 60 至 80 岁之间的高血压志愿者。他们进行了 16 周的阻力训练，强度为 1 最大重复的 50%。插入等位基因纯合子的最大益处是收缩压（SBP：129.31 ± 13.34 对 122.56 ± 9.68 mmHg，p <0.001）和舒张压（DBP：79.18 ± 8.05 对 70.12 ± 7.71 mmHg，p <0.01）在白天期间和 24 小时期间（SBP：127.12 ± 13.65 对 121.06± 9.68 mmHg，p <0.001 和 DBP：71.87 ± 8.39 对 68.75 ± 8.72 mmHg，p <0.05），也增加了循环脂联素水平（4.04 ± 1.79 对 6.00 ± 2.81 ng·ml，p <0.01）。其他基因型在血压和生化参数方面没有变化。我们的结果表明 I 等位基因是一种心脏保护因素，因为只有那些纯合子显示出血压降低和脂联素增加。
