Yoon Won Ho, Lee Keyong Ho
Department of Biotechnology, Seoil University, Jungnang-gu, Seoul, Korea.
Across, 23, Geodudanji 1-Gil, Chuncheon, Korea.
Biorheology. 2019;56(1):31-38. doi: 10.3233/BIR-190208.
Tamarind seed polysaccharide (TSP) is used as a texturizing agent and a thickener in food and pharmaceutical products. There are no publications describing the addition of TSP to intra-articular injection formulations for arthritis.
The purpose of this study was to investigate the rheology and efficacy of the formulation of TSP with hyaluronic acid (HA) as a new material for injection for arthritis.
We investigated the viscoelastic properties of formulations of HA and TSP as potential lubricants for arthritis, and tested the improvement of right/left paw weight distribution in monosodium iodoacetate-induced arthritis in the rat.
HA formulations with 3% and 4% TSP showed improved rheological characteristics and were protected against changes induced by heat sterilization. Addition of TSP also reduced pain in the arthritis model, as evidenced by normalization of the distribution of paw weight.
TSP is a potential material as a substitute for HA or in combination with HA for intra-articular injection for arthritis.
罗望子种子多糖（TSP）在食品和药品中用作增稠剂和质构改良剂。目前尚无关于将TSP添加到关节炎关节内注射制剂中的相关报道。
本研究旨在探究以透明质酸（HA）和TSP为原料的新型关节炎注射用制剂的流变学特性及疗效。
我们研究了HA和TSP制剂作为关节炎潜在润滑剂的粘弹性特性，并测试了其对碘乙酸钠诱导的大鼠关节炎右/左爪重量分布改善情况。
含3%和4% TSP的HA制剂显示出改善的流变学特性，且能抵御热灭菌引起的变化。添加TSP还减轻了关节炎模型中的疼痛，爪重量分布正常化证明了这一点。
TSP是一种有潜力的材料，可替代HA或与HA联合用于关节炎的关节内注射。
