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研究精油纳米乳剂-凝胶制剂的伤口愈合潜力。

Investigating the Wound-Healing Potential of a Nanoemulsion-Gel Formulation of Essential Oil.

作者信息

Bahloul Badr, Ben Bnina Enis, Hamdi Assia, Castillo Henríquez Luis, Baccar Dhaou, Kalboussi Nesrine, Abbassi Aïmen, Mignet Nathalie, Flamini Guido, Vega-Baudrit José Roberto

机构信息

Drug Development Laboratory LR12ES09, Faculty of Pharmacy, University of Monastir, Monastir 5000, Tunisia.

LR21AGR03-Production and Protection for a Sustainable Horticulture (2PHD), Regional Research Centre on Horticulture and Organic Agriculture, IRESA, University of Sousse, Chott Mariem 4042, Tunisia.

出版信息

Gels. 2024 Feb 20;10(3):155. doi: 10.3390/gels10030155.

DOI:10.3390/gels10030155
PMID:38534573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10970392/
Abstract

This study explores a nanoemulsion (NE)-based gel incorporating Tunisian essential oil, with a focus on its wound-healing potential. The essential oil, extracted via hydrodistillation, underwent GC-MS analysis for compositional verification. The physicochemical characterization included dynamic light scattering (DLS), transmission electron microscopy (TEM), zeta potential measurement, pH, and viscosity. The gelification of the NE facilitated topical application. The results revealed an average extraction yield of 0.45% and identified 38 compounds in the essential oil. The NE exhibited a particle size of 27 ± 0.4 nm, a polydispersity index (PDI) of 0.3, and a zeta potential of -22.8 ± 1.4 mV. The stability of the gelified preparation was confirmed through thermodynamic stability studies, TEM observations, and zeta and size results. In vivo experiments confirmed significant wound-healing effects, highlighting the promising role of the NE-based gel in healthcare advancements. This research underscores the potential of novel phyto-based delivery systems in wound care.

摘要

本研究探索了一种含有突尼斯精油的纳米乳液（NE）基凝胶，重点关注其伤口愈合潜力。通过水蒸馏提取的精油进行了气相色谱 - 质谱（GC-MS）分析以验证成分。物理化学表征包括动态光散射（DLS）、透射电子显微镜（TEM）、zeta电位测量、pH值和粘度。NE的凝胶化便于局部应用。结果显示平均提取率为0.45%，并在精油中鉴定出38种化合物。NE的粒径为27±0.4 nm，多分散指数（PDI）为0.3，zeta电位为-22.8±1.4 mV。通过热力学稳定性研究、TEM观察以及zeta电位和粒径结果证实了凝胶制剂的稳定性。体内实验证实了显著的伤口愈合效果，突出了NE基凝胶在医疗保健进步中的潜在作用。本研究强调了新型植物基递送系统在伤口护理中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/3c67a4f81432/gels-10-00155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/6431cb7c9c90/gels-10-00155-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/57d6f75bf286/gels-10-00155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/319179708278/gels-10-00155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/3c67a4f81432/gels-10-00155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/6431cb7c9c90/gels-10-00155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/c837ed1f4e05/gels-10-00155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/64d0903c7c1c/gels-10-00155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/d8722fa64f6e/gels-10-00155-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/57d6f75bf286/gels-10-00155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/319179708278/gels-10-00155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e6/10970392/3c67a4f81432/gels-10-00155-g007.jpg

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