School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Cancer Biomark. 2019;24(4):383-393. doi: 10.3233/CBM-181601.
Cancer, a deadly disease is characterized by abnormal cell growth with the potential to invade to other parts of the body. Most cancers start due to changes at gene level that happen over a person's lifetime when DNA repair system becomes faulty. CCDC6, one of the players in DNA repair system acts as a tumor suppressor gene. It was originally identified in chimeric genes caused by chromosomal translocation involving RET proto-oncogene in some thyroid tumors. Different fusion chimers with different proto-oncogenes like RET are known for CCDC6 which hampered its function. Further, CCDC6 is recognized as a pro-apoptotic phosphoprotein, which is an ATM substrate responsive to genotoxic stress. In this article, we reviewed the published literature to characterize CCDC6 fusions with proto-oncogenes and the role of natural phytochemicals which can potentially alter CCDC6 activity and thus can prove beneficial for cancer patients.
癌症是一种致命的疾病，其特征是异常细胞生长，并有可能侵入身体的其他部位。大多数癌症是由于一个人一生中基因水平的变化引起的，当 DNA 修复系统出现故障时，就会发生这种变化。CCDC6 是 DNA 修复系统的参与者之一，作为一种肿瘤抑制基因。它最初是在一些甲状腺肿瘤中涉及 RET 原癌基因的染色体易位引起的嵌合基因中被发现的。不同的融合嵌合体与不同的原癌基因如 RET 有关，这阻碍了 CCDC6 的功能。此外，CCDC6 被认为是一种促凋亡的磷酸蛋白，是 ATM 底物对遗传毒性应激的反应。在本文中，我们回顾了已发表的文献，以描述与原癌基因融合的 CCDC6 及其作用，以及天然植物化学物质可能改变 CCDC6 活性的作用，从而可能对癌症患者有益。
