Shiotani Akiko, Ishikawa Hideki, Mutoh Michihiro, Takeshita Tatsuya, Nakamura Tomiyo, Morimoto Kanehisa, Sakai Toshiyuki, Wakabayashi Keiji, Matsuura Nariaki
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan.
Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Asian Pac J Cancer Prev. 2019 Mar 26;20(3):795-799. doi: 10.31557/APJCP.2019.20.3.795.
Background: Recently, the number of colorectal cancer (CRC) cases in Japan has been increasing, and is strongly influenced by alcohol consumption. On the other hand, there are several reports suggesting a relationship between bowel movement (constipation and diarrhea) and CRC development. Moreover, it is generally known that diarrhea may occur after drinking. However, the mechanism by which drinking alcohol increases CRC is not fully clarified yet. We hypothesized that diarrhea after drinking may play an important role in colorectal carcinogenesis. Methods: We examined the presence of diarrhea after drinking and further evaluated the correlation of diarrhea after drinking with the incidence of colorectal tumors. To obtain the status of the feces, a self-recorded questionnaire survey was administered using the dietary-recording method. Blood samples were obtained to analyze the ALDH2 Glu504Lys and ADH1B His48Arg polymorphisms. Results: The participants were 417 patients who had undergone a total colonoscopy. The control was selected from 186 patients who underwent a medical checkup at the same hospital during the same time period. The odds ratio for all subjects was 2.1 (95% CI: 1.18 - 3.80), and that for heavy drinkers was 4.2 (1.48 - 11. 90). Conclusions: The results demonstrated that those who have diarrhea after drinking possess a high risk of developing colon tumors.
近年来，日本结直肠癌（CRC）病例数一直在增加，且受酒精消费的影响很大。另一方面，有几份报告表明排便（便秘和腹泻）与结直肠癌的发生之间存在关联。此外，众所周知，饮酒后可能会出现腹泻。然而，饮酒增加结直肠癌的机制尚未完全阐明。我们假设饮酒后腹泻可能在结直肠癌发生中起重要作用。方法：我们检查了饮酒后腹泻的情况，并进一步评估了饮酒后腹泻与结直肠肿瘤发病率的相关性。为了获取粪便状况，采用饮食记录法进行了自我记录问卷调查。采集血样以分析ALDH2 Glu504Lys和ADH1B His48Arg基因多态性。结果：参与者为417例接受全结肠镜检查的患者。对照组从同期在同一家医院进行体检的186例患者中选取。所有受试者的比值比为2.1（95%CI：1.18 - 3.80），重度饮酒者的比值比为4.2（1.48 - 11.90）。结论：结果表明，饮酒后腹泻的人患结肠肿瘤的风险很高。
