Avtsyn A P
Arkh Patol. 1986;48(5):3-11.
Aluminoses are widespread forms of trace element deficiency of various severity. The organism is protected against a possible pathogenic influence of aluminum by a number of physiological mechanisms the most important among which is a regular urine excretion. A complex of pathological symptoms develops if serious homeostasis disturbances take place e. g. when renal deficiency or direct penetration of the trace element occur. The following forms of aluminosis should be distinguished: 1) simple accumulation in central nervous system which occurs in persons over 65 years; 2) aluminum accumulation in Alzheimer disease, in severe form of presenile and senile dementia; 3) dialysis aluminum encephalopathy; 4) non-dialysis infantile encephalopathy; 5) aluminum encephalopathy in total parenteral nutrition; 6) iatrogenic dialysis aluminum osteodystrophy; 7) jatrogenic peritoneal aluminosis; 8) aluminum pneumoconiosis of an occupational origin; 9) bronchospastic syndrome in aluminum smelter workers.
铝中毒是各种严重程度的微量元素缺乏的普遍形式。机体通过多种生理机制来抵御铝可能产生的致病影响,其中最重要的是定期排尿。如果发生严重的体内平衡紊乱,例如当肾脏功能不足或微量元素直接侵入时,就会出现一系列病理症状。应区分以下几种铝中毒形式:1)在65岁以上人群中发生的单纯性铝在中枢神经系统的蓄积;2)铝在阿尔茨海默病、重度早老性和老年性痴呆中的蓄积;3)透析性铝脑病;4)非透析性婴儿脑病;5)全胃肠外营养中的铝脑病;6)医源性透析性铝骨营养不良;7)医源性腹膜铝中毒;8)职业性铝尘肺;9)炼铝工人的支气管痉挛综合征。