Rao J K, Katsetos C D, Herman M M, Savory J
Department of Pathology, University of Virginia, Charlottesville, USA.
Clin Lab Med. 1998 Dec;18(4):687-98, viii.
Alzheimer's disease has a complex pathogenesis and is a devastating neurologic disorder, predominantly of the elderly human population. Neuronal cell loss and neuritic pathology are a major neuropathologic feature of Alzheimer's disease, but there is no established mechanism to explain the degenerative process. The development of suitable animal systems would be of great value in helping to understand the basic mechanisms underlying the disease. We propose that the aluminum maltolate-treated elderly rabbit is a potentially useful animal system to model Alzheimer's disease neurofibrillary pathology. Details of such an experimental aluminum encephalopathy produced in the rabbit are discussed, along with other aspects of aluminum-induced neurodegeneration.
阿尔茨海默病具有复杂的发病机制，是一种主要影响老年人群的毁灭性神经疾病。神经元细胞丢失和神经病理改变是阿尔茨海默病的主要神经病理学特征，但尚无既定机制来解释这种退行性过程。开发合适的动物模型系统对于帮助理解该疾病的基本机制具有重要价值。我们提出，用麦芽酚铝处理的老年兔是一种潜在有用的动物模型系统，可用于模拟阿尔茨海默病的神经原纤维病理改变。本文讨论了在兔中产生的这种实验性铝脑病的详细情况，以及铝诱导神经退行性变的其他方面。
