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他莫昔芬与化疗作为Ⅲ期乳腺癌辅助治疗的比较

Tamoxifen versus chemotherapy as adjuvant treatment in stage III breast cancer.

作者信息

Alagaratnam T T, Wong J

出版信息

Aust N Z J Surg. 1986 Jan;56(1):39-41. doi: 10.1111/j.1445-2197.1986.tb01817.x.

DOI:10.1111/j.1445-2197.1986.tb01817.x
PMID:3090987
Abstract

A randomized prospective trial was conducted to compare Tamoxifen and combination chemotherapy (5-fluorouracil, doxorubicin and cyclophosphamide) as adjuvant treatment for patients with locally advanced (Stage III) breast cancer. At the end of 5 years, no significant difference could be found in the disease-free period for both groups.

摘要

进行了一项随机前瞻性试验，以比较他莫昔芬与联合化疗（5-氟尿嘧啶、阿霉素和环磷酰胺）作为局部晚期（III期）乳腺癌患者辅助治疗的效果。5年后，两组在无病期方面未发现显著差异。

相似文献

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Tamoxifen versus chemotherapy as adjuvant treatment in stage III breast cancer.他莫昔芬与化疗作为Ⅲ期乳腺癌辅助治疗的比较
Aust N Z J Surg. 1986 Jan;56(1):39-41. doi: 10.1111/j.1445-2197.1986.tb01817.x.
2
Radiotherapy, chemotherapy, and tamoxifen as adjuncts to surgery in early breast cancer: a summary of three randomized trials.早期乳腺癌手术辅助放疗、化疗及他莫昔芬治疗：三项随机试验综述
Int J Radiat Oncol Biol Phys. 1989 Mar;16(3):629-39. doi: 10.1016/0360-3016(89)90478-1.
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Adjuvant randomized trials of doxorubicin/cyclophosphamide versus doxorubicin/cyclophosphamide/tamoxifen and CMF chemotherapy versus tamoxifen in women with node-positive breast cancer.针对淋巴结阳性乳腺癌女性患者，多柔比星/环磷酰胺与多柔比星/环磷酰胺/他莫昔芬辅助随机试验以及CMF化疗与他莫昔芬辅助随机试验。
J Clin Oncol. 1993 Mar;11(3):454-60. doi: 10.1200/JCO.1993.11.3.454.
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Adjuvant chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide, with or without Bacillus Calmette-Guerin and with or without irradiation in operable breast cancer. A prospective randomized trial.
Cancer. 1984 Feb 1;53(3):384-9. doi: 10.1002/1097-0142(19840201)53:3<384::aid-cncr2820530303>3.0.co;2-g.
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Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15.在他莫昔芬无反应性肿瘤的阳性淋巴结乳腺癌患者中，比较含与不含间期再诱导治疗的两个月多柔比星-环磷酰胺方案与六个月环磷酰胺、甲氨蝶呤和氟尿嘧啶方案：国家外科辅助乳腺和肠道项目B-15的结果
J Clin Oncol. 1990 Sep;8(9):1483-96. doi: 10.1200/JCO.1990.8.9.1483.
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Adjuvant therapy in primary breast cancer.原发性乳腺癌的辅助治疗。
Surg Clin North Am. 1985 Feb;65(1):161-80. doi: 10.1016/s0039-6109(16)43540-1.
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Randomized trial of observation versus adjuvant therapy with cyclophosphamide, fluorouracil, prednisone with or without tamoxifen following mastectomy in postmenopausal women with node-positive breast cancer.绝经后淋巴结阳性乳腺癌患者乳房切除术后观察与环磷酰胺、氟尿嘧啶、泼尼松联合或不联合他莫昔芬辅助治疗的随机试验
J Clin Oncol. 1988 Sep;6(9):1388-96. doi: 10.1200/JCO.1988.6.9.1388.
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The prognosis of stage III breast cancer treated with postoperative radiotherapy and adriamycin-based chemotherapy with and without tamoxifen. Eight year follow-up results of a randomized trial.
Eur J Surg Oncol. 1995 Apr;21(2):146-50. doi: 10.1016/s0748-7983(95)90204-x.
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Chemotherapy versus tamoxifen versus chemotherapy plus tamoxifen in node-positive, estrogen receptor-positive breast cancer patients: results of a multicentric Italian study. Breast Cancer Adjuvant Chemo-Hormone Therapy Cooperative Group.在淋巴结阳性、雌激素受体阳性乳腺癌患者中，化疗与他莫昔芬及化疗加他莫昔芬的比较：一项意大利多中心研究结果。乳腺癌辅助化疗-激素治疗协作组
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