Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.
Mol Brain. 2019 Mar 25;12(1):23. doi: 10.1186/s13041-019-0444-5.
It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson's disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies.
现在普遍认为，骨骼的骨骼外功能是多方面的。当人们意识到成骨细胞（骨形成细胞）通过骨钙素（一种由成骨细胞分泌的多功能骨因子）改善葡萄糖代谢、胰岛素敏感性和能量消耗来维持能量平衡时，其内分泌功能首先引起了人们的注意。最近，关于这种骨因子功能方面的新知识扩展到包括成人和母体对认知功能的调节。这种骨因子在实验性帕金森病模型中的治疗潜力最近也有报道。本文综述了骨钙素在大脑中的功能，并强调了探索和分析更多深入的基础和临床研究的必要性。
