Nakamura Misa, Imaoka Masakazu, Takeda Masatoshi
Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
Int J Neurosci. 2021 Nov;131(11):1115-1123. doi: 10.1080/00207454.2020.1770247. Epub 2020 May 25.
Bone has conventionally been considered to be a passive organ that only receives external control, but according to recent findings, it has become clear that bone is an endocrine organ that actively regulates systemic metabolism through osteocalcin (OC).
We focus on the relationship between the brain and bone and summarize the effects of OC on cognitive function as well as the association between OC and improved cognitive function through exercise.
The findings suggest that the decrease in OC produced by bone is responsible for the decrease in cognitive function associated with aging. Furthermore, positive effect of improving cognitive function can generally be recognized in exercise interventions conducted for healthy elderly people and those with MCI, and moderate exercise is particularly effective for dementia prevention.
The improving bone health with aging may exert beneficial effects on cognition.
传统上，骨骼一直被视为一个仅接受外部控制的被动器官，但根据最近的研究结果，很明显骨骼是一个通过骨钙素（OC）积极调节全身代谢的内分泌器官。
我们关注大脑与骨骼之间的关系，总结OC对认知功能的影响以及OC与通过运动改善认知功能之间的关联。
研究结果表明，骨骼产生的OC减少是与衰老相关的认知功能下降的原因。此外，在针对健康老年人和轻度认知障碍患者进行的运动干预中，通常可以认识到改善认知功能的积极效果，适度运动对预防痴呆症尤其有效。
随着年龄增长改善骨骼健康可能对认知产生有益影响。
