Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
National Children's Research Centre, Crumlin, Dublin, Ireland.
J Perinatol. 2019 May;39(5):626-633. doi: 10.1038/s41372-019-0354-5. Epub 2019 Mar 25.
The objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD).
A prospective cohort study of 20 infants with DS without CHD and 17 healthy term infants comparing echocardiographic measures of left (LV) and right (RV) ventricular function and pulmonary hypertension (PH) on days 1, 2, and 5-7.
Indices of PH were higher in the DS group over the study period. Infants with DS had larger RV and smaller LV dimensions. Fractional area change and RV longitudinal strain values were lower in the DS group. LV shear strain values were lower in infants with DS driven by a lack of basal rotation.
Infants with DS without CHD and echocardiographic evidence of PH during the early neonatal period demonstrate reduced RV systolic function with impaired LV rotational mechanics, reflective of the ventricular interdependence.
本研究旨在测试无先天性心脏病（CHD）的唐氏综合征（DS）婴儿在出生后第一周内的心肌功能是否受损。
对 20 名无 CHD 的 DS 婴儿和 17 名健康足月婴儿进行前瞻性队列研究，比较两组婴儿在第 1、2 天以及第 5-7 天的左（LV）、右（RV）心室功能和肺动脉高压（PH）的超声心动图指标。
在研究期间，DS 组的 PH 指数更高。DS 组婴儿的 RV 尺寸更大，LV 尺寸更小。DS 组的分数面积变化和 RV 纵向应变值较低。由于基底旋转不足，DS 组婴儿的 LV 切应变值较低。
在新生儿早期，无 CHD 且超声心动图显示 PH 的 DS 婴儿表现出 RV 收缩功能降低，LV 旋转力学受损，反映了心室间的相互依存关系。
