Cavalletti E, Tofanetti O, Zunino F
Cancer Lett. 1986 Jul;32(1):1-6. doi: 10.1016/0304-3835(86)90032-7.
Since the usefulness of high-dose cyclophosphamide is often limited by hemorrhagic cystitis, and the use of sulfhydryl-containing compounds prevents this side effect, this study was carried out to compare the uroprotective efficacy of 2-mercaptoethane sulfonate (MESNA) with that of reduced glutathione. In experimentally cyclophosphamide-induced urotoxicity in mice, the protective efficacy and potency of these thiols were similar, since both agents afforded complete protection in the same dose range. This finding suggests that these compounds are suitable sources of urinary thiols. Although the rationale for the clinical use of these protectors is similar, glutathione may have therapeutic advantages over MESNA because of a wider margin of safety and multiple protective actions displayed by the tripeptide thiol.
由于高剂量环磷酰胺的有效性常受出血性膀胱炎限制，而使用含巯基化合物可预防此副作用，因此开展本研究以比较2-巯基乙烷磺酸钠（美司钠）与还原型谷胱甘肽的尿路保护效果。在实验性环磷酰胺诱导的小鼠尿路毒性中，这些硫醇的保护效果和效能相似，因为两种药物在相同剂量范围内均提供完全保护。这一发现表明这些化合物是合适的尿硫醇来源。尽管这些保护剂临床应用的基本原理相似，但由于三肽硫醇具有更宽的安全范围和多种保护作用，谷胱甘肽可能比美司钠具有治疗优势。
