Freedman A, Ehrlich R M, Ljung B M
J Urol. 1984 Sep;132(3):580-2. doi: 10.1016/s0022-5347(17)49751-5.
The ability of 2-mercaptoethane sodium sulfonate to prevent histologic damage to the bladder from cyclophosphamide was studied. Male rats receiving 2-mercaptoethane sodium sulfonate in conjunction with cyclophosphamide had a statistically significant decrease in ulceration, inflammation and edema of the bladder compared to those treated with cyclophosphamide alone. Most bladders of animals given prophylactic 2-mercaptoethane sodium sulfonate with a dose of cyclophosphamide were histologically indistinguishable from controls receiving neither drug. The relevance of these findings to the short and long-term effects of cyclophosphamide on the urothelium is discussed.
研究了2-巯基乙烷磺酸钠预防环磷酰胺对膀胱组织学损伤的能力。与单独接受环磷酰胺治疗的雄性大鼠相比，同时接受2-巯基乙烷磺酸钠和环磷酰胺的雄性大鼠膀胱的溃疡、炎症和水肿在统计学上有显著降低。给予预防性2-巯基乙烷磺酸钠和一定剂量环磷酰胺的动物的大多数膀胱在组织学上与未接受任何药物的对照组无异。讨论了这些发现与环磷酰胺对尿路上皮的短期和长期影响的相关性。
