1 Department of Cardiothoracic Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, China.
2 Department of Urology, Children's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, China.
Int J Biol Markers. 2019 Jun;34(2):168-175. doi: 10.1177/1724600819831404. Epub 2019 Mar 26.
Numerous studies have suggested that dyslipidemia is closely related to various cancers and the high-density lipoprotein cholesterol (HDL-C) levels are associated with the outcome of cancer patients. However, the predictive value of HDL-C in patients with renal cell carcinoma remains unclear. Our study aims to explore the relationship between the levels of serum HDL-C and the prognosis of renal cell carcinoma.
A total of 308 patients diagnosed with clear cell renal cell carcinoma (CCRCC) who received surgical treatment were retrospectively enrolled in our study. The necessary clinical data of each enrolled patient were collected and the Kaplan-Meier method and the Cox proportional hazards regression model were used to calculate the overall survival and cancer-specific survival.
Kaplan-Meier and univariate analysis showed that a lower preoperative serum HDL-C level was a risk factor of CCRCC patients. Multivariate analyses demonstrated that a higher serum HDL-C level was closely associated with better overall survival (hazard ratio = 0.32; 95% confidence interval (0.13, 0.78); =0.013) and cancer-specific survival (hazard ratio =0.42; 95% confidence interval (0.15, 0.99); =0.048).
Our findings suggest that an increased serum level of HDL-C might predict better overall survival and cancer-specific survival in patients with CCRCC.
许多研究表明，血脂异常与各种癌症密切相关，高密度脂蛋白胆固醇（HDL-C）水平与癌症患者的预后相关。然而，HDL-C 水平在肾细胞癌患者中的预测价值尚不清楚。本研究旨在探讨血清 HDL-C 水平与肾细胞癌预后的关系。
回顾性纳入 308 例接受手术治疗的透明细胞肾细胞癌（CCRCC）患者。收集每位入组患者的必要临床数据，采用 Kaplan-Meier 法和 Cox 比例风险回归模型计算总生存率和癌症特异性生存率。
Kaplan-Meier 分析和单因素分析显示，术前血清 HDL-C 水平较低是 CCRCC 患者的危险因素。多因素分析表明，较高的血清 HDL-C 水平与更好的总生存率（风险比=0.32；95%置信区间（0.13，0.78）；=0.013）和癌症特异性生存率（风险比=0.42；95%置信区间（0.15，0.99）；=0.048）密切相关。
我们的研究结果表明，血清 HDL-C 水平升高可能预示着 CCRCC 患者的总生存率和癌症特异性生存率更好。
