Que Yi, Jiang Feng, Liu Liting, Li Yuanfang, Chen Yongming, Qiu Haibo, Zhou Zhiwei, Zhang Xing
From the State Key Laboratory of Oncology in South China (YQ, FJ, XZ); Department of Gastric and Pancreatic Surgery (YL, YC, HQ, ZZ); Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China (LL).
Medicine (Baltimore). 2015 May;94(18):e844. doi: 10.1097/MD.0000000000000844.
The prognostic value of lipid profile remains unclear in soft tissue sarcoma. The aim of the present study was to validate the prognostic value of preoperative plasma lipid profile (high density lipoprotein-cholesterol [HDL-C], low density lipoprotein-cholesterol [LDL-C], cholesterol, and triglycerides) levels on disease-free survival (DFS) and overall survival (OS) in soft tissue sarcoma (STS) patients undergoing extensive and radical surgical resection.The preoperative plasma lipid profile levels of 234 STS patients, who were operated on between 2000 with 2010, were retrospectively evaluated. Kaplan-Meier curves and multivariate Cox proportional models were calculated for DFS and OS.In univariate analysis, a decreased HDL-C level was significantly associated with decreased OS (hazard ratio [HR], 3.405; 95% confidence interval (CI), 1.445-8.021, P = 0.005) and remained significant in the multivariate analysis (HR, 5.615; 95% CI, 1.243-25.378, P = 0.025). Patients with HDL-C < 1.475 mmol/L showed a median OS of 71 months. In contrast, patients with HDL-C ≥1.475 mmol/L had a median OS of 101 months. In univariate analysis, a decreased HDL-C level was significantly associated with decreased DFS (HR, 2.085; 95% CI, 1.271-3.422, P = 0.004) and remained significant in the multivariate analysis (HR, 1.808; 95% CI, 1.118-2.924, P = 0.016). Patients with HDL-C <1.475 mmol/L presented with a median DFS of 47 months, whereas patients with HDL-C ≥1.475 mmol/L had a median DFS of 78 months. In univariate analysis and multivariate analyses regarding OS and DFS, there was no significant association between the groups in terms of LDL-C, CHO and TG.Our study investigated the potential prognostic utility of preoperative plasma HDL-C levels as an independent factor in STS patients who had undergone radical surgical resection.
脂质谱在软组织肉瘤中的预后价值仍不清楚。本研究的目的是验证术前血浆脂质谱（高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]、胆固醇和甘油三酯）水平对接受广泛根治性手术切除的软组织肉瘤（STS）患者无病生存期（DFS）和总生存期（OS）的预后价值。回顾性评估了2000年至2010年间接受手术的234例STS患者的术前血浆脂质谱水平。计算了DFS和OS的Kaplan-Meier曲线和多变量Cox比例模型。单因素分析中，HDL-C水平降低与OS降低显著相关（风险比[HR]，3.405；95%置信区间[CI]，1.445 - 8.021，P = 0.005），多因素分析中仍具有显著性（HR，5.615；95% CI，1.243 - 25.378，P = 0.025）。HDL-C < 1.475 mmol/L的患者中位OS为71个月。相比之下，HDL-C≥1.475 mmol/L的患者中位OS为101个月。单因素分析中，HDL-C水平降低与DFS降低显著相关（HR，2.085；95% CI，1.271 - 3.422，P = 0.004），多因素分析中仍具有显著性（HR，1.808；95% CI，1.118 - 2.924，P = 0.016）。HDL-C < 1.475 mmol/L的患者中位DFS为47个月，而HDL-C≥1.475 mmol/L的患者中位DFS为78个月。在关于OS和DFS的单因素分析和多因素分析中，LDL-C、CHO和TG组间无显著关联。我们的研究调查了术前血浆HDL-C水平作为接受根治性手术切除的STS患者独立因素的潜在预后效用。
