Jiang M J, Zhang H J, Li W R, Wu W Q, Huang Y M, Xu D M, Qi Y Y, Qin K Y, Zhang L, Zhang J L
a Department of Neurology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.
b Department of Urology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.
Neurol Res. 2019 Mar;41(3):199-203. doi: 10.1080/01616412.2018.1520438.
Objective To investigate the diagnostic value of electroencephalogram (EEG) complexity in patients with neurosyphilis by comparing the changes of electroencephalogram Lempel-Ziv complexity (EEG-LZC) before and after anti-syphilis treatment. Methods The EEG complexity of neurosyphilis patients diagnosed in our hospital from July in 2015 to June in 2017 was analyzed and compared with other diagnostic results such as serology examination and cerebrospinal fluid examination. Results A total of 27 patients were diagnosed, including 19 males and 8 females, of which 6 were mesenchymal(cerebrospinal membrane and meningeal vascular), 16 were parenchymal(paralytic dementia, spinal cord tuberculosis and optic neuropathy), and 5 were asymptomatic. After intensive anti-syphilis therapy, the LZC increased significantly in all patients while the trend and degree of change were consistent with other diagnostic results. Conclusion The LZC can be used as one of the diagnostic indexes meanwhile the trend and degree of its change can be used as the reference index of curative effect to neurosyphilis.
目的 通过比较抗梅毒治疗前后脑电图莱姆尔 - 齐夫复杂度（EEG - LZC）的变化，探讨脑电图复杂性在神经梅毒患者中的诊断价值。方法 分析2015年7月至2017年6月在我院确诊的神经梅毒患者的脑电图复杂性，并与血清学检查、脑脊液检查等其他诊断结果进行比较。结果 共诊断出27例患者，其中男性19例，女性8例，其中间质性（脑脊膜和脑膜血管）6例，实质性（麻痹性痴呆、脊髓痨和视神经病变）16例，无症状性5例。经过强化抗梅毒治疗后，所有患者的LZC均显著增加，且变化趋势和程度与其他诊断结果一致。结论 LZC可作为诊断指标之一，其变化趋势和程度可作为神经梅毒疗效的参考指标。
