医护人员接触电离辐射后的甲状腺功能。

Thyroid Function in Health Care Workers Exposed to Ionizing Radiation.

机构信息

Occupational Health and Prevention Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.

Radiological Protection Service, Fundación Jiménez Díaz University Hospital, Madrid, Spain.

出版信息

Health Phys. 2019 Oct;117(4):403-407. doi: 10.1097/HP.0000000000001071.

DOI:10.1097/HP.0000000000001071

PMID:30913057

Abstract

OBJECTIVES

To analyze possible alterations of thyroid function related to dosimetric values in health care workers exposed to ionizing radiation.

MATERIALS AND METHODS

Forty-six health care workers exposed to ionizing radiation at a tertiary hospital previously exposed to ionizing radiation were included in the study. Age, sex, history of thyroid diseases, thyroid hormones, work post, service, dosimetric values of previous year, and 5 y period were considered. Alterations of thyroid function and other variables were analyzed by exact logistic regression univariate model.

RESULTS

7.1% workers showed an increased serum thyroid-stimulating hormone without free T3 or free T4 alteration. A significant relationship between workers with increased thyroid-stimulating hormone and dosimetric values of previous year (odds ratio 6.35, 95% confidence interval 1.20-98.1, p = 0.021) and previous 5 y period of radiation exposure (odds ratio 1.72, 95% confidence interval 1.12-3.34, p = 0.007) was obtained.

CONCLUSION

An increased risk of subclinical hypothyroidism related to radiation doses was observed in this pilot study on a group of health care workers exposed to ionizing radiation.

摘要

目的

分析与接触电离辐射的医护人员剂量学值相关的甲状腺功能变化。

材料和方法

本研究纳入了 46 名曾在一家三级医院接触过电离辐射的医护人员。考虑了年龄、性别、甲状腺疾病史、甲状腺激素、工作岗位、工作年限、前一年的剂量学值以及 5 年期间。通过单变量精确逻辑回归模型分析了甲状腺功能改变和其他变量。

结果

7.1%的工人表现出血清促甲状腺激素升高，而游离 T3 或游离 T4 没有改变。在接受过增加的甲状腺刺激激素的工人和前一年（优势比 6.35，95%置信区间 1.20-98.1，p = 0.021）和前 5 年的辐射暴露（优势比 1.72，95%置信区间 1.12-3.34，p = 0.007）的剂量学值之间存在显著关系。