Tu L, Wang S L, Dong Q, Song H Y, Li X T, Tan C P, Dong X
Nanjing Prevention and Treatment Center for Occupational Diseases, Nanjing 210042, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Feb 20;36(2):91-94. doi: 10.3760/cma.j.issn.1001-9391.2018.02.003.
We evaluated the effect of low-dose of ionizing radiation on thyroid function of medical occupational group with long-term exposure; furthermore; we analyzed the relationship between the thyroid hormones and the risk factors; such as exposure length; department. Ultimately; providing the scientific basis for setting the ionizing radiation protection standards. The population who engaged radiodiagnosis and radiotherapy in a tertiary-A hospital were set up as occupational exposure; 724 medical professionals as the research object. We figured out the basic information and general condition of the groups by face-to-face questionnaire survey; By means of the thyroid hormone testing; we analyzed the thyroid hormone levels with different population; occupational exposure factors. Then; obtained the prevalence of thyroid nodules by the thyroid ultrasound. Besides; we used the logistic regression model to analyze the risk factors related to thyroid nodule. Applying Epidata、Excel in data management. All the data was analyzed by statistical software package Stata12.0. Descriptive statistics; single factor analysis of variance and other statistical methods were used for data analysis. Test standard: α=0.05、<0.05 statistical significant. 1. Based on the work experience; we divided the study population into four groups; such as 1-9; 10-19; 20-29; and>30 years. The difference of the TSH level among the four groups was statistically significant (<0.05) . 2. The multiple logistic regression showed that sex and seniority were the independent risk factors for the abnormal rate of thyroid nodules. Long-term exposure to low-dose ionizing radiatiom could induce the thyroid damage of medical occupational population; which should be broader concerned.
我们评估了低剂量电离辐射对长期暴露的医疗职业人群甲状腺功能的影响；此外，我们分析了甲状腺激素与暴露时长、科室等危险因素之间的关系。最终，为制定电离辐射防护标准提供科学依据。将某三甲医院从事放射诊断和放射治疗的人员设为职业暴露组，选取724名医学专业人员作为研究对象。通过面对面问卷调查了解各组的基本信息和一般情况；借助甲状腺激素检测，分析不同人群、职业暴露因素下的甲状腺激素水平。然后，通过甲状腺超声检查得出甲状腺结节的患病率。此外，我们使用逻辑回归模型分析与甲状腺结节相关的危险因素。应用Epidata、Excel进行数据管理。所有数据均采用统计软件包Stata12.0进行分析。采用描述性统计、单因素方差分析等统计方法进行数据分析。检验水准：α = 0.05，P<0.05为差异有统计学意义。1. 根据工作年限，将研究人群分为1 - 9年、10 - 19年、20 - 29年和>30年四组。四组TSH水平差异有统计学意义（P<0.05）。2. 多因素逻辑回归显示，性别和工龄是甲状腺结节异常率的独立危险因素。长期低剂量电离辐射暴露可导致医疗职业人群甲状腺损伤，应予以更广泛关注。
