去甲肾上腺素能投射至室旁核中断后摄食行为的变化：组织化学和神经化学分析

Changes in ingestive behavior following interruption of a noradrenergic projection to the paraventricular nucleus: histochemical and neurochemical analyses.

作者信息

O'Donohue T L, Crowley W R, Jacobwitz D M

出版信息

Pharmacol Biochem Behav. 1978 Jul;9(1):99-105. doi: 10.1016/0091-3057(78)90018-7.

Abstract

Histochemical investigation of the paraventricular nucleus (PVN) identified the tractus filiformis lateralis (TF) as a major noradrenergic preterminal pathway to the PVN. Bilateral knife cuts transecting the TF resulted in a discrete deafferentation of 56% of the noradrenergic input to the PVN region. TF transection also resulted in hypophagia and hypodipsia during the first four days after surgery. A marked hyperdipsia developed between postoperative Days 11 and 13 and persisted until sacrifice on Day 17. The results suggest that the TF contains a noradrenergic system which innervates the PVN and is involved in mediation of ingestive behaviors.

摘要

对室旁核（PVN）的组织化学研究表明，外侧丝状束（TF）是通往PVN的主要去甲肾上腺素能终末前通路。双侧切断TF会导致PVN区域56%的去甲肾上腺素能输入出现离散性脱失。TF横断还会在术后头四天导致摄食减少和饮水减少。术后第11天至第13天之间出现明显的烦渴，并持续到第17天处死时。结果表明，TF含有一个去甲肾上腺素能系统，该系统支配PVN并参与摄食行为的调节。