O'Donohue T L, Crowley W R, Jacobowitz D M
Brain Res. 1979 Aug 17;172(1):87-100. doi: 10.1016/0006-8993(79)90897-7.
Norepinephrine (NE) and dopamine (DA) concentration and dopamine turnover were measured 12 days after a unilateral or bilateral noradrenergic ventral bundle (VB) transection to determine the noradrenergic projection sites and possible interactions with dopaminergic systems. Both bilateral and unilateral VB transection resulted in a significant reduction of NE of the nucleus accumbens, lateral septal nucleus, medial forebrain bundle, ventromedial nucleus, dorsomedial nucleus and medial amygdaloid nucleus. Bilateral transection also decreased NE content of the median eminence and the periventricular and arcuate nuclei. In the medial preoptic nucleus, the nucleus interstitialis striae terminalis and the central gray catecholamine area, bilateral transection significantly decreased NE concentrations while unilateral lesions had no significant effect. The anterior hypothalamic, lateral preoptic, and paraventricular nuclei responded to bilateral VB transection with a decrease in NE concentration and to unilateral lesion with a bilateral increase in NE. In the dorsal hippocampus and the caudate nucleus, bilateral lesions had no effect on NE concentrations while unilateral transection significantly decreased NE concentrations. Regions in which neither bilateral nor unilateral VB transection produced a significant change in NE content are the olfactory tubercle, the nucleus tractus diagonalis, substantia nigra pars compacta and reticulata, ventral tegmental area, habenula, superior colliculus, and the cingulate and piriform cortices. Transection of the noradrenergic ventral bundle also produced changes in dopaminergic systems suggesting a noradrenergic--dopaminergic interaction. Bilateral VB transection decreased the dopamine concentration and turnover in the nucleus accumbens, increased steady-state levels and turnover in the nucleus tractus diagonalis and increased dopamine concentration in the lateral septum. Unilateral VB transection decreased DA concentration bilaterally in the caudate nucleus, olfactory tubercle, nucleus accumbens and the nucleus interstitialis striae terminalis but increased concentrations in the substantia nigra pars reticulata (ipsilateral) and in the ventral tegmental area (bilateral). These results indicate a broad projection field for the noradrenergic ventral bundle and suggest a noradrenergic--dopaminergic interaction.
在单侧或双侧去甲肾上腺素能腹侧束（VB）横断12天后，测量去甲肾上腺素（NE）和多巴胺（DA）浓度以及多巴胺周转率，以确定去甲肾上腺素能投射部位以及与多巴胺能系统可能存在的相互作用。双侧和单侧VB横断均导致伏隔核、外侧隔核、内侧前脑束、腹内侧核、背内侧核和内侧杏仁核中NE显著减少。双侧横断还降低了正中隆起、室周核和弓状核中的NE含量。在内侧视前核、终纹床核间质性核和中央灰质儿茶酚胺区，双侧横断显著降低了NE浓度，而单侧损伤则无显著影响。下丘脑前部、外侧视前区和室旁核在双侧VB横断后NE浓度降低，而在单侧损伤后NE双侧升高。在背侧海马和尾状核中，双侧损伤对NE浓度无影响，而单侧横断则显著降低了NE浓度。双侧和单侧VB横断均未使NE含量产生显著变化的区域有嗅结节、斜角带核、黑质致密部和网状部、腹侧被盖区、缰核、上丘以及扣带回和梨状皮质。去甲肾上腺素能腹侧束的横断也引起了多巴胺能系统的变化，提示去甲肾上腺素能-多巴胺能相互作用。双侧VB横断降低了伏隔核中的多巴胺浓度和周转率，增加了斜角带核中的稳态水平和周转率，并增加了外侧隔核中的多巴胺浓度。单侧VB横断使尾状核、嗅结节、伏隔核和终纹床核间质性核中的DA浓度双侧降低，但使黑质网状部（同侧）和腹侧被盖区（双侧）中的浓度升高。这些结果表明去甲肾上腺素能腹侧束具有广泛的投射区域，并提示去甲肾上腺素能-多巴胺能相互作用。
