HIV 暴露前预防项目入组患者中解脲支原体感染及大环内酯类耐药的高流行率。
High prevalence of Mycoplasma genitalium infection and macrolide resistance in patients enrolled in HIV pre-exposure prophylaxis program.
机构信息
Infectious and tropical diseases department, Pellegrin hospital, Bordeaux university hospital, 33000 Bordeaux, France.
USC EA 3671, Mycoplasma and chlamydia human infections, Bordeaux university, 33000 Bordeaux, France; USC EA 3671, Mycoplasma and chlamydia human infections, French National Institute for Agricultural Research, 33000 Bordeaux, France; Bacteriological laboratory, Bordeaux university hospital, 33000 Bordeaux, France.
出版信息
Med Mal Infect. 2019 Aug;49(5):347-349. doi: 10.1016/j.medmal.2019.03.007. Epub 2019 Mar 23.
OBJECTIVES
Limited data on Mycoplasma genitalium infection has been reported among PrEP users. The aim of this study was to estimate the prevalence and macrolide resistance of M. genitalium infection among enrollees in a French PrEP program.
PATIENTS AND METHODS
M. genitalium infection screening was systematically and prospectively proposed to patients of the Bordeaux PrEP program (between January 2016 and February 2017). Macrolide resistance was evaluated in M. genitalium-positive patients.
RESULTS
Among 89 clients, M. genitalium infection prevalence was 10% (mainly asymptomatic) with a high rate of macrolide resistance (58%).
CONCLUSIONS
Because of a high level of macrolide resistance, a systematic search for M. genitalium macrolide resistance associated-mutations may be recommended in PrEP users before initiating the antibiotic therapy.
目的
关于暴露前预防（PrEP）使用者中支原体属生殖器感染的数据有限。本研究旨在估计法国 PrEP 项目参与者中支原体属生殖器感染的流行率和大环内酯类耐药率。
患者和方法
2016 年 1 月至 2017 年 2 月，对波尔多 PrEP 项目的患者系统地、前瞻性地提出了支原体属生殖器感染筛查。对支原体属生殖器感染阳性患者进行了大环内酯类耐药评估。
结果
在 89 名患者中，支原体属生殖器感染的流行率为 10%（主要为无症状），大环内酯类耐药率较高（58%）。
结论
由于大环内酯类耐药率较高，建议在开始抗生素治疗前，对接受 PrEP 的患者进行支原体属生殖器大环内酯类耐药相关突变的系统检测。
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