Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, 12120, Thailand.
Curr Allergy Asthma Rep. 2019 Mar 26;19(5):29. doi: 10.1007/s11882-019-0860-8.
Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases.
The effector Th9 cells differentiating from naïve T helper cells have recently been identified. Because of accumulating findings of Th9 cells in many inflammatory diseases, including allergic diseases, diverse functions of Th9 cells in regulating immune responses have been suggested. Related reports indicate multiple sources of IL-9 besides Th9 cells and their association with the pathogenesis of allergic rhinitis, asthma, atopic dermatitis, contact dermatitis, and food allergy. More recently, elements of the epigenetic landscape involving in the regulation of IL-9 by Th9 cells have been identified to be the potential target for allergic inflammation. This review provides the most recent information about Th9 cells and their contribution in airway allergic disease, skin, and food allergy.
Th9 细胞被认为是一种新型效应 T 辅助细胞亚群，其优先产生白细胞介素-9。本文就 Th9 细胞在过敏性炎症性疾病中的功能的相关研究进展作一综述。
从幼稚 T 辅助细胞中分化而来的效应 Th9 细胞最近已被鉴定。由于 Th9 细胞在多种炎症性疾病（包括过敏性疾病）中的积累发现，提示 Th9 细胞在调节免疫反应中具有多种功能。相关研究表明，除 Th9 细胞以外，还有多种来源的白细胞介素-9，其与变应性鼻炎、哮喘、特应性皮炎、接触性皮炎和食物过敏的发病机制有关。最近，涉及 Th9 细胞调控白细胞介素-9 的表观遗传景观的相关元素被确定为过敏性炎症的潜在靶点。本综述提供了关于 Th9 细胞及其在气道过敏性疾病、皮肤和食物过敏中作用的最新信息。
