Institute of Ultrasound Imaging of Chongqing Medical University, Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Yuzhong Distinct, Chongqing, 400010, P. R. China.
Biomater Sci. 2019 Apr 23;7(5):1815-1824. doi: 10.1039/c8bm01658e.
It is a great challenge to directly endow a tumor with specific functions for theranostic treatment. In this study, we report on a novel approach to transform a tumor into a "bio-magnet", to be magnetized on demand, in order to create an intrinsic tumor magnetic field that would collect magnetic nanoparticles (MNPs) circulating in the blood and achieve simultaneous magnetic hyperthermia. This was achieved by the localized intratumoral injection of liquid Nd2Fe14B/Fe3O4-PLGA, followed by solvent exchange that induces a liquid-to-solid transformation. After the magnetism charging process, the solid Nd2Fe14B/Fe3O4-PLGA implant was endowed with permanent magnetic properties and in situ created the magnetic field within the tumor tissue, making the tumor a "bio-magnet". After the creation of the bio-magnet, intravenously injected MNPs accumulated into the tumor tissue due to the tumor magnetic field. Importantly, both the in vitro and ex vivo results demonstrated the high efficiency of the implanted bio-magnet for magnetic hyperthermia. This new approach achieves magnetic targeting by creating a tumor "bio-magnet", which generates a strong magnetic field within the tumor, paving a new way for the development of an efficient targeting strategy for tumor therapy.
直接赋予肿瘤特定的治疗诊断功能是一个巨大的挑战。在这项研究中，我们报告了一种将肿瘤转化为“生物磁体”的新方法，可以按需磁化，以产生内在的肿瘤磁场，从而收集血液中循环的磁性纳米颗粒（MNPs）并实现磁热疗。这是通过局部瘤内注射液体 Nd2Fe14B/Fe3O4-PLGA 并进行溶剂交换来实现的，该溶剂交换会诱导液体到固体的转变。在磁化充电过程之后，固体 Nd2Fe14B/Fe3O4-PLGA 植入物具有永久磁性，并在肿瘤组织内原位产生磁场，使肿瘤成为“生物磁体”。在创建生物磁体后，由于肿瘤磁场，静脉注射的 MNPs 聚集到肿瘤组织中。重要的是，体外和离体结果都证明了植入生物磁体用于磁热疗的高效性。这种新方法通过创建肿瘤“生物磁体”来实现磁性靶向，在肿瘤内产生强磁场，为肿瘤治疗的高效靶向策略的发展开辟了新途径。
