亚甲基四氢叶酸还原酶多态性与肝细胞癌的相关性：一项荟萃分析。

Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis.

机构信息

Department of Pediatrics, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Gastrointestinal Surgery, Tengzhou Central People's Hospital, Zaozhuang, China,

出版信息

Ann Nutr Metab. 2019;74(3):251-256. doi: 10.1159/000496428. Epub 2019 Mar 27.

DOI:10.1159/000496428

PMID:30917367

Abstract

BACKGROUND

The correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) remains controversial.

OBJECTIVES

We performed this study to better assess the relationship between MTHFR gene polymorphisms and the likelihood of HCC.

METHODS

A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. ORs and 95% CIs were calculated.

RESULTS

A total of 15 studies with 8,378 participants were analyzed. In overall analyses, a significant association with the likelihood of HCC was detected for the rs1801131 polymorphism with fixed-effect models (FEMs) in recessive comparison (p = 0.002, OR 0.62, 95% CI 0.43-0.82). However, no positive results were detected for the rs1801133 polymorphism in any comparison. Further subgroup analyses revealed that the rs1801131 polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: p < 0.0001, OR 0.42, 95% CI 0.29-0.62; allele model: p = 0.004, OR 1.20, 95% CI 1.06-1.35) and random-effect models (recessive model: p = 0.002, OR 0.47, 95% CI 0.29-0.75). Nevertheless, we failed to detect any significant correlation between the rs1801133 polymorphism and HCC.

CONCLUSIONS

Our findings indicated that the rs1801131 polymorphism may serve as a genetic biomarker of HCC in Asians.

摘要

背景

亚甲基四氢叶酸还原酶（MTHFR）基因多态性与肝细胞癌（HCC）之间的相关性仍存在争议。

目的

我们进行这项研究是为了更好地评估 MTHFR 基因多态性与 HCC 发生的可能性之间的关系。

方法

通过对 PubMed、Medline 和 Embase 进行系统的文献检索，检索到相关文章。计算了 OR 值和 95%CI。

结果

共分析了 15 项研究，共 8378 名参与者。在总体分析中，采用固定效应模型（FEM）进行隐性比较时，rs1801131 多态性与 HCC 的发生显著相关（p = 0.002，OR 0.62，95%CI 0.43-0.82）。然而，在任何比较中，都没有检测到 rs1801133 多态性的阳性结果。进一步的亚组分析显示，rs1801131 多态性与亚洲人群 HCC 的发生显著相关，无论是采用 FEM（隐性模型：p < 0.0001，OR 0.42，95%CI 0.29-0.62；等位基因模型：p = 0.004，OR 1.20，95%CI 1.06-1.35）还是随机效应模型（隐性模型：p = 0.002，OR 0.47，95%CI 0.29-0.75）。然而，我们未能检测到 rs1801133 多态性与 HCC 之间存在任何显著相关性。