亚甲基四氢叶酸还原酶基因多态性与青光眼的相关性：一项荟萃分析。

Correlation between MTHFR polymorphisms and glaucoma: A meta-analysis.

作者信息

Zhang Ling, Chen Bin

机构信息

Department of Ophthalmology, People's Hospital of Leshan, Leshan, China.

出版信息

Mol Genet Genomic Med. 2019 Apr;7(4):e00538. doi: 10.1002/mgg3.538. Epub 2019 Mar 9.

DOI:10.1002/mgg3.538

PMID:30851082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6465672/

Abstract

BACKGROUND

Whether methylenetetrahydrofolate reductase (MTHFR) polymorphisms are implicated in glaucoma remains controversial. Therefore, we performed this study to better assess the relationship between MTHFR polymorphisms and the likelihood of glaucoma.

METHODS

A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

RESULTS

A total of 18 studies with 7,168 participants were analyzed. In overall analyses, a significant association with the likelihood of glaucoma was detected for the rs1801133 polymorphism in dominant (p = 0.04, OR = 0.90, 95%CI 0.81-1.00) and allele (p = 0.02, OR = 0.91, 95%CI 0.84-0.98) comparisons. Further, subgroup analyses by ethnicity revealed that both rs1801131 and rs1801133 polymorphisms were significantly associated with the likelihood of glaucoma in West Asians. However, no positive results were detected for two investigated polymorphisms in East Asians and Caucasians.

CONCLUSION

Our findings indicated that rs1801131 and rs1801133 polymorphisms may serve as genetic biomarkers of glaucoma in West Asians.

摘要

背景

亚甲基四氢叶酸还原酶（MTHFR）基因多态性与青光眼是否有关仍存在争议。因此，我们进行了这项研究，以更好地评估MTHFR基因多态性与患青光眼可能性之间的关系。

方法

对PubMed、Medline和Embase进行系统检索以获取相关文章。计算比值比（OR）和95%置信区间（CI）。

结果

共分析了18项研究，涉及7168名参与者。在总体分析中，rs1801133基因多态性在显性（p = 0.04，OR = 0.90，95%CI 0.81 - 1.00）和等位基因（p = 0.02，OR = 0.91，95%CI 0.84 - 0.98）比较中与患青光眼的可能性存在显著关联。此外，按种族进行的亚组分析显示，rs1801131和rs1801133基因多态性在西亚人中均与患青光眼的可能性显著相关。然而，在东亚人和高加索人中，所研究的两种多态性均未得出阳性结果。