Kim Jae-Yong, Shim Sang Hee
Colleage of Pharmacy, Duksung Woman's University, Seoul 01369, Republic of Korea.
Biomol Ther (Seoul). 2019 May 1;27(3):254-264. doi: 10.4062/biomolther.2018.231.
Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol, fats, and other substances in the tunica intima which leads to narrowing of the blood vessels, loss of elasticity, and arterial wall thickening, thus causing difficulty in blood flow. Natural products have been used as one of the most important strategies for the treatment and prevention of cardiovascular diseases for a long time. In recent decades, as interests in natural products including medicinal herbs have increased, many studies regarding natural compounds that are effective against atherosclerosis have been conducted. The purpose of this review is to provide a brief overview of the natural compounds that have been used for the treatment and prevention of atherosclerosis, and their mechanisms of action based on recent research.
动脉粥样硬化是一种广泛存在的慢性进行性动脉疾病，被认为是全球主要死因之一。它是由胆固醇、脂肪和其他物质在血管内膜沉积引起的，导致血管狭窄、弹性丧失和动脉壁增厚，从而造成血流困难。长期以来，天然产物一直被用作治疗和预防心血管疾病的最重要策略之一。近几十年来，随着对包括草药在内的天然产物的兴趣增加，人们对有效对抗动脉粥样硬化的天然化合物进行了许多研究。这篇综述的目的是基于最近的研究，简要概述已用于治疗和预防动脉粥样硬化的天然化合物及其作用机制。
