Aronstam A, Dennis B, Friesen M J, Clark W F, Linton A L, Lindsay R M
Thromb Haemost. 1978 Jun 30;39(3):695-700.
Heparin neutralizing activity (HNA) was increased in plasma of patients with end-stage renal disease treated by maintenance haemodialysis. It was not raised in non-dialyzed patients with chronic renal failure, nor in patients with normal renal function who had been exposed to the extracorporeal circulation of the heart-lung bypass 48--72 hr before testing. It is postulated that the trauma of extracorporeal circulation causes platelets to release HNA which is not cleared by the dialysis membranes of the artificial kidney but is by the human kidney. This may have therapeutic implications for heparin dosage schedules during haemodialysis.
维持性血液透析治疗的终末期肾病患者血浆中的肝素中和活性（HNA）升高。在未透析的慢性肾衰竭患者以及肾功能正常但在检测前48 - 72小时接受过心肺旁路体外循环的患者中，HNA并未升高。据推测，体外循环的创伤会导致血小板释放HNA，这种物质不能被人工肾的透析膜清除，但能被人体肾脏清除。这可能对血液透析期间的肝素给药方案具有治疗意义。
