Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Adv Exp Med Biol. 2019;1134:259-269. doi: 10.1007/978-3-030-12668-1_14.
The ATPase family AAA-domain containing protein 3A (ATAD3A), a nuclear-encoded mitochondrial enzyme, is involved in diverse cellular processes, including mitochondrial dynamics, cell death and cholesterol metabolism. Overexpression and/or mutation of the ATAD3A gene have been observed in different types of cancer, associated with cancer development and progression. The dysregulated ATAD3A acts as a broker of a mitochondria-endoplasmic reticulum connection in cancer cells, and inhibition of this enzyme leads to tumor repression and enhanced sensitivity to chemotherapy and radiation. As such, ATAD3A is a promising drug target in cancer treatment.
ATP 酶家族 AAA 结构域包含蛋白 3A（ATAD3A）是一种核编码的线粒体酶，参与多种细胞过程，包括线粒体动力学、细胞死亡和胆固醇代谢。在不同类型的癌症中观察到 ATAD3A 基因的过表达和/或突变，与癌症的发展和进展有关。失调的 ATAD3A 在癌细胞中充当线粒体-内质网连接的经纪人，抑制这种酶可抑制肿瘤生长，并增强对化疗和放疗的敏感性。因此，ATAD3A 是癌症治疗中有前途的药物靶点。
