Patel Akshay J, Hunt Ian
Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Department of Thoracic Surgery, Heartland's Hospital, UHB NHS Trust, Birmingham, UK.
Interact Cardiovasc Thorac Surg. 2019 Aug 1;29(2):287–290. doi: 10.1093/icvts/ivz082. Epub 2019 Mar 28.
A best evidence topic in thoracic surgery was written in accordance to a structured protocol. The question addressed was: 'In patients with a pectus excavatum deformity, is vacuum bell therapy (VBT) an effective treatment?' Altogether, 19 papers were found using the reported search of which 7 represented the best evidence to answer the clinical questions. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Numerous groups have demonstrated the utility of VBT in pectus excavatum; the largest series has followed up patients over 13 years with sternal elevation of >1 cm being demonstrated in 105 patients. Initial age <11, initial chest wall depth <1.5 cm and chest wall flexibility have all been associated with better outcomes. The effects of VBT have been confirmed on computed tomography scanning and intraoperatively to lift the sternum to facilitate retrosternal soft tissue dissection during the Nuss procedure. There was significant heterogeneity in the studies reviewed, in terms of patient age, selection criteria, the VBT protocol, length of follow-up time following completion of VBT and the metrics used to assess success of therapy. VBT is a safe therapy for treating pectus excavatum in a non-surgical conservative manner with few complications reported. However, the success of VBT is largely dependent on patient compliance and motivation. Permanence of correction after completion of VBT needs to be properly assessed through rigorous follow-up, and currently the success of correction, i.e. permanence, remains in the hands of the patient.
一篇胸外科最佳证据主题文章是按照结构化方案撰写的。所探讨的问题是:“对于漏斗胸畸形患者,真空吸盘疗法(VBT)是否为一种有效的治疗方法?”通过报告的检索共找到19篇论文,其中7篇代表了回答该临床问题的最佳证据。这些论文的作者、期刊、发表日期和国家、所研究的患者组、研究类型、相关结局和结果均列于表格中。许多研究组已证明VBT在漏斗胸治疗中的效用;最大规模的系列研究对患者进行了超过13年的随访,105例患者的胸骨抬高超过1厘米。初始年龄<11岁、初始胸壁深度<1.5厘米以及胸壁柔韧性均与更好的结局相关。VBT的效果已在计算机断层扫描和术中得到证实,可抬高胸骨以利于在Nuss手术期间进行胸骨后软组织解剖。在所审查的研究中,在患者年龄、选择标准、VBT方案、VBT完成后的随访时间长度以及用于评估治疗成功的指标方面存在显著异质性。VBT是以非手术保守方式治疗漏斗胸的一种安全疗法,报告的并发症较少。然而,VBT的成功很大程度上取决于患者的依从性和积极性。VBT完成后矫正的持久性需要通过严格的随访进行适当评估,目前矫正的成功,即持久性,仍取决于患者。