Müller Daniel A, Silvan Unai
Biomechanics Laboratory, University Hospital Balgrist, University of Zürich, Zürich, Switzerland.
Int J Dev Biol. 2019;63(1-2):1-8. doi: 10.1387/ijdb.190019us.
Although rare among the general population, bone malignancies have a high rate of incidence among children and adolescents and are associated with high mortality rates. Osteosarcoma (also known as osteogenic sarcoma) is the most frequent primary cancer of bone and shows a high tendency to metastasize to the lung. Despite the frequent use of osteosarcoma-derived cell lines in basic biomechanical research and for the evaluation of cell responses to new biomaterials, the mechanical phenotype and the differences between osteosarcoma cells and related cell types, such as mesenchymal cells, osteoblasts and osteocytes, remain largely unknown. In the present review we summarize current knowledge of the biophysical and mechanical properties of the niche of primary osteosarcomas and of the malignant cells, and discuss the impact of these features on the progression of malignancy.
尽管骨恶性肿瘤在普通人群中较为罕见，但在儿童和青少年中发病率较高，且死亡率也很高。骨肉瘤（也称为成骨肉瘤）是最常见的原发性骨癌，极易转移至肺部。尽管在基础生物力学研究以及评估细胞对新型生物材料的反应中经常使用骨肉瘤衍生的细胞系，但骨肉瘤细胞与相关细胞类型（如间充质细胞、成骨细胞和骨细胞）之间的力学表型及差异仍 largely unknown。在本综述中，我们总结了原发性骨肉瘤微环境及恶性细胞的生物物理和力学特性的现有知识，并讨论了这些特征对恶性肿瘤进展的影响。 （注：“largely unknown”直译为“很大程度上未知”，这里为保留原文风格未做意译调整）
