Center for Translational Research on Autoimmune and Allergic Diseases, Università del Piemonte Orientale, Novara, Italy.
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.
Tissue Eng Part B Rev. 2024 Apr;30(2):217-229. doi: 10.1089/ten.TEB.2023.0106. Epub 2023 Nov 16.
In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment remains a challenge, and osteosarcoma-the most common primary bone cancer-is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness, thus making this component of the microenvironment a mandatory requirement to the developed models. In this review, we addressed the question: is the "" gap in osteosarcoma engineering bridged from the perspective of biomechanical stimuli? The most notable biomechanical cues in the tumor cell microenvironment are observed and compared in the contexts of conditions and engineered three-dimensional models. Impact statement The importance of biomechanical stimuli in three-dimensional models for drug testing is becoming more pronounced nowadays. This review might assist in understanding the key players of the biophysical environment of primary bone cancer and the current state of bone tumor engineering from this perspective.
在过去几十年中，抗癌药物的发展需要强大的测试系统，这将肿瘤工程领域提升到了一个新的水平。模拟肿瘤微环境仍然是一个挑战，骨肉瘤——最常见的原发性骨癌也不例外。越来越多的证据表明，生物力学刺激与肿瘤化疗敏感性和侵袭性之间存在必然联系，因此，微环境的这一组成部分成为开发模型的强制性要求。在这篇综述中，我们提出了一个问题：从生物力学刺激的角度来看，骨肉瘤工程中的“鸿沟”是否已经弥合？在 条件和工程三维 模型的背景下，观察和比较了肿瘤细胞微环境中最显著的生物力学线索。 影响评估 生物力学刺激在用于药物测试的三维 模型中的重要性如今变得更加明显。从这个角度来看，本篇综述可能有助于理解原发性骨癌的生物物理环境的关键因素以及骨肿瘤工程的现状。
