Treatment of SE has improved considerably during the last decade. Mortality from SE itself should be minimal if effective treatment is delivered rapidly. Currently, the risk of complications from appropriate treatment is less than the risk of injury from additional seizures. Loading with phenytoin, 20 mg per kg, using benzodiazepam if needed, is the current treatment of choice. If seizures persist, phenobarbital 10 to 20 mg per kg should be used. If convulsive SE continues for more than 1 hour, pentobarbital coma is necessary.
在过去十年中,癫痫持续状态(SE)的治疗有了显著改善。如果能迅速进行有效治疗,SE本身导致的死亡率应降至最低。目前,适当治疗引发并发症的风险低于癫痫发作增加所造成损伤的风险。当前的治疗首选方案是静脉给予 20mg/kg 的苯妥英钠,必要时可使用苯二氮䓬类药物。若癫痫发作仍持续,应使用 10 - 20mg/kg 的苯巴比妥。若惊厥性 SE 持续超过 1 小时,则有必要采用戊巴比妥昏迷疗法。