Wheless James W, Treiman David M
LeBonheur Children's Medical Center, University of Tennessee, Memphis, Tennessee 38105, USA.
Epilepsia. 2008 Dec;49 Suppl 9:74-8. doi: 10.1111/j.1528-1167.2008.01929.x.
The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.
癫痫发作的紧急治疗是一个重要的实际问题，尤其是全面性惊厥性癫痫持续状态（GCSE）的治疗。苯二氮䓬类药物或较老的标准抗癫痫药物（苯巴比妥、苯妥英）通常被用作GCSE的初始静脉治疗药物。随着新型胃肠外抗癫痫药物的研发，且更多药物即将问世，关于它们在癫痫持续状态（SE）治疗中的作用也引发了一些问题。本综述讨论了GCSE治疗的相关证据，包括新型药物（丙戊酸盐、左乙拉西坦）。我们将SE的治疗与我们对潜在神经生理学和癫痫发作持续时间的现代理解联系起来。
