Department of Pediatrics, Division of Pediatric Cardiology, The Congenital Heart Collaborative, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland Medical Center, Cleveland, Ohio.
Birth Defects Res. 2019 May 1;111(8):395-399. doi: 10.1002/bdr2.1499. Epub 2019 Mar 28.
Congenital heart disease (CHD), the most common of birth defects, can be serious enough to require a lifetime of medical care including multiple surgeries or other interventions. Advances in ultrasound technology and a better understanding of the progression of CHDs have made it possible to intervene in utero. This early stage intervention allows the still plastic cardiovascular system to return to a more normal trajectory thus sparing the newborn from negative consequences to morbidity and mortality. Fetal cardiac intervention (FCI) has been successful for the alleviation of left ventricular dysfunction resulting in remarkably positive outcomes for many families. Promising results support that FCI may also be useful in alleviating right ventricular dysfunction. This bodes well for expanding the use of FCI to lead to better postnatal adaptation and improved long-term function for more children with CHD.
先天性心脏病（CHD）是最常见的出生缺陷，严重程度足以需要终生的医疗护理，包括多次手术或其他干预。超声技术的进步和对 CHD 进展的更好理解使得宫内干预成为可能。这种早期干预使仍处于发育中的心血管系统恢复到更正常的轨迹，从而使新生儿免受发病率和死亡率的负面影响。胎儿心脏介入（FCI）已成功缓解左心室功能障碍，为许多家庭带来了显著的积极结果。有希望的结果支持 FCI 也可能有助于缓解右心室功能障碍。这预示着将 FCI 应用范围扩大，将为更多患有 CHD 的儿童带来更好的出生后适应和长期功能改善。
