Department of Ophthalmology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey
Department of Ophthalmology, Sandıklı State Hospital, Afyonkarahisar, Turkey
Turk J Med Sci. 2019 Aug 8;49(2):1041-6. doi: 10.3906/sag-1901-22.
BACKGROUND/AIM: The aim of the current study was to evaluate the correlation between the integrity of the outer retinal layers on optical coherence tomography (OCT) and objective parameters of retinal microvascular perfusion on optical coherence tomography angiography (OCTA).
A total of 105 eyes of 54 diabetic patients were included in the study. Integrity of the outer retinal layers including the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ) was assessed by spectral-domain optical coherence tomography. The foveal avascular zone (FAZ) area and vessel density (VD) measurements in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in all the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors were evaluated by OCTA. Associations between the quantitative measurement of the FAZ and retinal VD measurements and outer retinal disruptions were evaluated.
The FAZ area was correlated with outer retinal layer disruption both in the superficial plexus (r = 0.244, 0.228, 0.212, P = 0.013, 0.02, 0.031 for the ELM, EZ, and IZ, respectively) and the deep capillary plexus (r = 0.298, 0.234, 0.197, P = 0.002, 0.019, 0.048 for the ELM, EZ, and IZ, respectively). A significant relationship was also found between the VD measurements in the SCP and DCP in ETDRS sectors and the outer retinal layers disruption.
The results of the current study show a significant relationship between the quantitative OCTA parameters and the integrity of the outer retinal layers. This finding reveals a correlation between retinal capillary nonperfusion and outer retinal disruption in eyes with diabetic retinopathy.
背景/目的：本研究旨在评估光学相干断层扫描（OCT）中外层视网膜完整性与光相干断层扫描血管造影（OCTA）中视网膜微血管灌注客观参数之间的相关性。
共纳入 54 例 105 只糖尿病患者的眼。采用频域光相干断层扫描仪评估外视网膜层（包括外节层（ELM）、椭圆体带（EZ）和内节带（IZ））的完整性。采用 OCTA 评估所有早期糖尿病视网膜病变研究（ETDRS）区域中浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的中心凹无血管区（FAZ）面积和血管密度（VD）测量值。评估 FAZ 定量测量值与视网膜 VD 测量值和外层视网膜破坏之间的相关性。
FAZ 面积与浅层丛（r = 0.244、0.228、0.212，P = 0.013、0.02、0.031，ELM、EZ 和 IZ 分别）和深层毛细血管丛（r = 0.298、0.234、0.197，P = 0.002、0.019、0.048，ELM、EZ 和 IZ 分别）中外层视网膜破坏均相关。还发现 ETDRS 区域中 SCP 和 DCP 的 VD 测量值与外层视网膜层破坏之间存在显著关系。
本研究结果表明，OCTA 定量参数与外层视网膜完整性之间存在显著关系。这一发现揭示了糖尿病视网膜病变眼中视网膜毛细血管无灌注与外层视网膜破坏之间的相关性。
